Is a Colonoscopy Painful? What Patients Should Know Colonoscopy can seem scary for some people due to the fear of pain and discomfort during the procedure, as well as the results doctors will come up with. However, knowing how colonoscopy works can relieve patients' fears. Colonoscopy is a very significant medical procedure that allows doctors to look into digestive system disorders, detect abnormal tissues, and diagnose colorectal cancer at its...